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How Does For ADHD Work? Many people find that their symptoms improve when they take medication. Finding the right drug in the right dosage takes time, open communication and a willingness to listen to your GP. The medications that treat ADHD are effective by altering the levels of certain chemical messengers in your brain. Drugs that stimulate the brain, such as methylphenidate can help reduce impulsivity and hyperactivity, and improve focus. Atomoxetine (Strattera) and guanfacine (Tenex, Intuni