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Being redox-active, these metals work as cofactors in the enzymatic reactions of electron transfer. Nonetheless, under pathophysiological circumstances, due to their particular large redox potentials, they may exacerbate stress-induced damage. This may be specifically dangerous to your liver - the main human body reservoir of the two metals. Amazingly, the participation of Cu and Fe in liver pathology nevertheless remains badly grasped. Hypoxic stress into the structure may behave as a stimulus that mob