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It is often difficult to accurately predict how a melanoma will progress because melanomas can be so diverse in their genetic and histological makeup. We sought to characterize the current state and progression of biomedical markers towards their utilization as prognostic indicators for patients with melanoma. A literature search of the research repository databases PubMed and GoogleScholar was conducted using the following inclusion criteria (1) published within the last 10 years, and (2) use of overall survival, disease progression, or