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007). Maximal muscle strength of the knee flexors (decreased in the control group pɳ2 0.139), strength endurance of the knee extensors (decreased in the hEDS/HSD group and increased in the control group pɳ2 0.244) and muscle density (decreased in the hEDS/HSD group pɳ2 0.263) showed a significantly different evolution over eight years. No other significant differences in evolution were found. CONCLUSION Decreased muscle strength was identified at both time points in patients with hEDS/HSD. The evolution of most muscle strength parameter