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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD find their symptoms improve through medication. Each person's reaction to drugs is different, and the side effects can be problematic. Methylphenidate is a stimulant. It works by increasing levels of a chemical in the brain that aids in controlling the attention span and behavior. Stimulant medication Stimulant medications enhance attention and concentration in 70% to 80% of children and adults who take th