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We attempt to identify specific differentially methylated and expressed genes in people with longevity family history, it will contribute to discover significant features about human longevity. A prevalence study was conducted during October 2017 to January 2019 in Bama County of Guangxi, China and individuals were recruited and grouped into longevity family (n=6 and non-longevity family (n=6 to identify differentially methylated genes (DMGs). The expression profile dataset GSE16717 was downloaded from the GEO database in which indi