https://sulforhodamine101.com/....damaging-decay-speed
Here, we reveal that removal of RNA 5-methylcytosine (m5C) methyltransferase Nsun2 in mouse CD4+ T cells specifically inhibits Th17 cell differentiation and alleviates Th17 cell-induced colitis pathogenesis. Mechanistically, RoRγt can recruit Nsun2 to chromatin areas of their particular targets, including Il17a and Il17f, causing the transcription-coupled m5C formation and consequently enhanced mRNA stability. Our research shows a m5C mediated cell intrinsic function in Th17 cells and indi
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