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2% of HAdV-7and HAdV-3 infected children, respectively. Further, viremia was strongly associated with severe clinical presentations. The pathogenesis of HAdV-7-induced severe disease was probably associated with high replication competence and hyper-inflammatory responses. The detection of adenovirus DNA in blood may be useful for severe disease risk-assessment. The pathogenesis of HAdV-7-induced severe disease was probably associated with high replication competence and hyper-inflammatory responses. The detection of adenovirus DNA in b
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