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16mg/mL) while piperine exhibited the highest MAO inhibitory effect (IC =0.21mg/mL). Berberine, piperine and neostigmine exhibited high antioxidant properties and inhibited Fe , cisplatin and SNP induced LPO Both alkaloids demonstrated antiradical scavenging ability comparable to neostigmine action against Alzheimer's disease (AD). The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurode
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