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The conclusions clearly show that climate change could create new areas in Europe with suitable climates for H. marginatum, while keeping its "historical" distribution in the Mediterranean. Therefore, it is necessary to further explore possible risk areas for H. marginatum and its associated pathogens.In bone regeneration, obtaining a vital bone as similar as possible to native bone is sought. This review aimed to evaluate the efficacy of stem cells in maxillary bone regeneration for implant rehabilitation and to review the different tec