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CONCLUSION about the good effect of cryotherapy on arteriovenous fistula puncture-related discomfort, cryotherapy as a low-risk and simple procedure is apparently effective and useful in reducing discomfort and ultimately lowering its unpleasant psychological and actual complications. OBJECTIVES Much epidemiological evidence links diabetes mellitus (DM) into the development of numerous cancers and, in certain, the development of hepatocellular carcinoma (HCC). The purpose of this research would be