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001). The NPS was superior to other systemic inflammatory and nutritional index for predicting prognoses, as determined using area under the curves (P 0.05). Multivariate analysis demonstrated that the NPS was a significant predictor of poor RFS (Group 1 hazard ratio [HR] 1.897, P = 0.049; Group 2 HR 3.979, P 0.001) and OS (Group 1 HR 2.152, P = 0.033; Group 2 HR 3.239, P = 0.006). The present study demonstrated that NPS was an independent prognostic factor in patients with locally advanced ESCC and more reliable and accurate than the other system