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BACKGROUND ARID1A is described as a tumor suppressor gene, taking part in chromatin re-modeling, epithelial-mesenchymal-transition and many various other mobile and molecular processes. It is often cited as a contribute in tumorigenesis. The role of ARID1A in CRC isn't yet defined. Seek to research the role of ARID1A methylation and CNV in its appearance in CRC cellular lines and to examine the connection between ARID1A condition with survival and clinicopathologic faculties in clients