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Our study provides a strategy for designing new biomimetic materials, which may be favorable in the treatment of refractory bone fracture.Background The nanotechnologies have been applied for dental restorative materials manufacturing such as glass ionomer cement, composites, tooth regeneration, and endodontic sealers. The study aimed to investigate the chemical bond of conventional glass ionomer cement and to evaluate the addition of different concentrations of silver nanoparticles (AgNPs) on the quality of the chemical bond of glass i