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Atrial fibrillation (AF) is a common arrhythmia that adversely affects health-related quality of life (HRQoL). We conducted a pilot trial of individuals with AF using a smartphone to provide a relational agent as well as rhythm monitoring. We employed our pilot to measure acceptability and adherence and to assess its effectiveness in improving HRQoL and adherence. This study aims to measure acceptability and adherence and to assess its effectiveness to improve HRQoL and adherence. Participants were recruited from ambulatory clinics and