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The Most Effective ADHD Medication For Adults Adults suffering from ADHD are usually prescribed stimulants. They help adjust levels of two chemical messengers within the brain that control the attention. The most effective medication for adhd for adults is Strattera (atomoxetine). It comes as an oral capsule that can be taken with or without food. The majority of people find it to be effective. It lasts longer than less powerful stimulants, like methylphenidate or amphetamin