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ymptoms. Future research is needed to confirm these findings in survivors of critical illness. To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries. Retrospective observational study. ICUs of two tertiary hospitals, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark. Adult patients with antibiotic treatment greater than or equal to 72 hours and vasopressor therapy