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The study aimed to methodically review alterations in serum hepcidin levels during weight and aerobic exercise programs. A systemic literary works search from 2010 to April 2020 across seven databases made up of Cochrane library , PubMed, Web of Science, Scopus, Embase, MEDLINE, and OpenGrey. The principal result was increased or reduced serum hepcidin from standard after the workout activity. Dangers of bias were assessed by usin showed significant boost in serum hepcidin and IL-6 levels i