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Hence physical activity as a means to prevent or delay the onset of T2D was indeed possible but meaningful answers could only be found in large-scale intervention trials which should be well-designed and use appropriate tools that objectively evaluate physical activity, as seen in intervention trials carried out in the following years. The present paper attempts to indicate the most salient studies that conform to the suggestions made in this trailblazing study for preventing or delaying T2D, and suggest future research This article is