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How Does ADHD Medication Work? When a neuron sends an information to another, it makes use of neurotransmitters or chemicals. They must cross a tiny gap called the synapse. Some ADHD medications can increase the efficiency of these messages. They can aid neurons in releasing more neurotransmitters or slow down the process of reuptake (called reuptake inhibitors). Doctors begin ADHD patients with a lower dose and monitor their reaction. They alter the dosage over time to det