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Golden standard of acute stroke treatment is recanalisation therapy. However, opening the occluded blood vessel sometimes does not show the expected clinical result or leads to haemorrhagic complications. As neuroinflammation and neurotoxicity play an important role in the pathophysiology of stroke, neuroprotective agents might preserve brain tissue after futile recanalisation. After recanalisation therapy and not later than 24h after symptoms onset, patients with initial NIHSS of ≥8 were assigned to the investigational and control grou