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In addition, she has brachycephaly, never described in female DDX3X patients, and macroglossia, that has never been associated with the syndrome. This case expands the knowledge of DDX3X pathogenic variants and the associated DDX3X syndrome phenotypic spectrum. This case expands the knowledge of DDX3X pathogenic variants and the associated DDX3X syndrome phenotypic spectrum. Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post