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We used AMBER DNA parmOL15 and RNA parmOL3 force fields and tested different ion and liquid designs. DNA two-quartet parallel-stranded GQs unfolded in most the simulations while the comparable RNA GQ ended up being stable generally in most regarding the simulations. GQs consists of two stacked products of two-quartet GQs were steady both for DNA and RNA. The simulations declare that at the least three quartets are required to form an intrinsically stable all-anti