https://www.selleckchem.com/pr....oducts/limertinib.ht
The objective response rate (ORR) to ICIs was 75% (nine out of 12) in solid tumor patients with high TMB and 25% (30 out of 4 in those with non-high TMB. Patients with high TMB had better ORR to ICIs than those with non-high TMB ( = 0.004). Univariate analysis revealed that the status of PD-L1 expression and of TMB (high non-high) had significant association in response to ICIs. However, in multivariate analysis, the status of TMB (high non-high) was only significantly related to the response to ICIs ( = 0.036). In the present st
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