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Furthermore, NOTCH3, but not NOTCH1, physically bound to ZIP4. Collectively, our data suggest that ZIP4 is a novel CSC marker and the new ZIP4-NOTCH3 axis represents important therapeutic targets in HGSOC.The use of piles as barriers to mitigate vibrations from rail traffic has been increasing in theoretical and practical engineering during the last years. Tyre-derived aggregate (TDA) is a recycled material with some interesting applications in civil engineering, including those related to railway engineering. As a novelty, this paper