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These are explained in detail in the following review. This review will also provide an impetus for more studies on the role of microRNAs in breast cancer. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Vascular dysfunction is common in obesity. Insulin can directly modulate arterial function, but its role is unclear in obesity. We examined the influence of adiposity on the direct effects of insulin on human artery responses. METHODS 22 healthy women were stratified by median BMI