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How Does Medication For ADHD Work? The stimulants are among the most commonly used ADHD medications prescribed. They work by increasing the levels of brain chemicals, called dopamine and norepinephrine. They include methylphenidate (Ritalin, Concerta), amphetamine, dextroamphetamine (Adderall) and Lisdexafetamine (Vyvanse). These are typically prescribed in long-release