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The Most Effective ADHD Medication For Adults Adults with ADHD are usually prescribed stimulants. They aid in regulating levels of two chemical signals in the brain that regulate the attention. The most effective adhd medication for adults is Strattera (atomoxetine). It is available in capsules that can be taken with food or without. Most people find it effective. It is also more effective than shorter-acting stimulants, such as amphetamine or methylphenidate. 1. Strattera Strattera (atomoxetine)