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Upper extremity activity-based therapy for neurologic disorders employs high-intensity, high repetition functional training to exploit neuroplasticity and improve function. Research focused on high-intensity upper extremity activity-based therapy for persons with spinal cord injury (SCI) is limited. To summarize high-intensity activity-based interventions used in neurological disorders for their current or potential application to SCI. The scoping review included articles from MEDLINE, CINAHL, Cochrane CENTRAL, and OTseeker with the cr