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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can lead to chronic underachievement and depression. This is particularly true when they fail their personal and professional objectives. The overlapping symptoms of the comorbidities of ADHD and depression can make it challenging to get an accurate diagnosis. Recognizing the symptoms is a good first step towards seeking treatment. 1. Feelings of Inadequacy Untreated ADHD and co-occ