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The percentage of increase was 83.30% and 36.60% respectively. While the infected group recorded a non-significant decrease in AST level and the percentage of decrease was - 7.4%. Immunocompetent groups showed a positive significant correlation with the control Mirazid or control PZQ groups recorded an increase in liver function enzymes (AST, Bilirubin, and GGT) (P less then 0.001) comparing to the normal control group. In conclusion, Mirazid showed higher cure rates than PZQ, 95.45%, and 74.54% on the 15th and the 21st days, it reached