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The worldwide research initiatives on Corona Virus disease 2019 lockdown effect on air quality agree on pollution reduction, but the most reliable method to pollution reduction quantification is still in debate. In this paper, machine learning models based on a Gradient Boosting Machine algorithm are built to assess the outbreak impact on air quality in Quito, Ecuador. First, the precision of the prediction was evaluated by cross-validation on the four years prelockdown, showing a high accuracy to estimate the real pollution levels. The