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Furthermore, ADSC sheet enhanced adiponectin appearance when you look at the subcutaneous adipose tissues in HF/HSD-fed mice, whereas it paid off TNF-α phrase into the visceral adipose cells. ADSC-CM enhanced and reduced the protein levels of adiponectin and TNF-α in 3T3-L1 adipocytes, respectively. In conclusion, we first revealed that ADSC sheet transplantation into the subcutaneous internet sites improves glucose intolerance in mice fed with HF/HSD. Modifications of adiponectin and T
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