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Changes in FC in large-scale neural networks are likely involved in occupational stress responses. Taken together, these results suggest that proper management of occupational stress may help prevent the occurrence of clinical problems caused by changes in brain functional networks. The purpose of this study is to investigate if an orally administered combination of aspirin and ketamine will provide better analgesia than a ketamine alone in adult patients presenting to the Emergency Department (ED) with acute musculoskeletal pain. We con