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As wild birds are an important species in biology and agriculture, their genome modifying has gained considerable interest and is primarily performed by making use of a primordial germ cellular (PGC)-mediated method because pronuclear injection isn't practical within the avian species. In this method, PGCs may be isolated, cultured, genetically edited in vitro, and injected into a recipient embryo to create GE offspring. Recently, a few GE quail have been produced ut