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These data demonstrate that MHCTCR signaling can be required to initiate a cancer phenotype from an understudied developmental state that appears to be represented in the mouse and human disease spectrum. There are concerns on the potential impact of the COVID-19 outbreak on patients with inflammatory bowel disease (IBD). To report the impact of the COVID-19 outbreak in a European prospective cohort study of patients with IBD. We prospectively collected data from 5,457 patients with IBD nested in the ongoing I-CARE project and still fol