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Sleeve gastrectomy (SG) has become the most prevalent bariatric-metabolic surgical approach in the United States. Its popularity among surgeons and patients is mainly due to a better safety profile and less overall morbidity, with broad benefits from a systemic and metabolic perspective. Comprehensively describe the short-term multiorgan metabolic effects of rapid weight loss after SG. Academic hospital, United States. We retrospectively reviewed the charts of patients that underwent SG at our institution between 2012 and 2016. We analy