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In Egypt, there are 8.9 million adult diabetics using almost 16 million insulin injection devices daily. Unsafe disposal of these sharps will result in many environmental and public health hazards. This study aimed at evaluating knowledge and practice of diabetic patients toward safe disposal of insulin injection devices. Cross-sectional study and health education sessions were carried out at diabetic outpatient clinic of the Internal Medicine Department, Tanta University Hospitals in Middle Delta, Egypt, during a period of 2 months (No