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49; 95% CI 4.25-13.20, = .0001) or needed to be treated with a bypass (HR 1.79; 95% CI 1.05-3.05, = .034) were at an increased risk for major amputation. Increased mortality rate was noted after endovascular procedures (HR 1.45; 95% CI 1.04-2.00, = .026). This retrospective study with comparable results for DR and IR did not support the angiosome concept. Achieving wound healing remains critical in patients with CLTI to reduce major amputation rates. Overall the implications of the angiosome concept seem to be limited due to its feasibility in pati