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This review will briefly summarize information on exosome membrane proteins components and their role in exosome-cell interactions, including proteins associated with specific cell-interactions and diseases, and the potential for using exosome membrane proteins in therapeutic targeting approaches. © The Author(s) 2020. Published by Oxford University Press on behalf of West China School of Medicine West China Hospital of Sichuan University.Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose an