https://www.selleckchem.com/pr....oducts/ly2606368.htm
relation between docking score and BACE-1 inhibition profile. Compounds substituted with m-benzyloxy on one aromatic ring and o,p-di-chloro on another aromatic ring displayed maximum BACE-1 inhibition. Compound 2.13A displayed high docking score and was found to be most potent with IC50 of 6.92µM. The series displayed a good correlation between docking score and BACE-1 inhibition profile. Consolidation of current research findings as well as the most important concepts regarding neutrophil extracellular traps (NETs) in rheumatoid arth
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