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The C allele of rs7528684 ended up being related to MS, together with CC genotype may lead to the upregulation of FCRL3 expression and also the increase in IL-10 secretion. More in vitro experiments with B cells found that lipopolysaccharide (LPS) presented FCRL3 expression in a dose- and time-dependent manner, thereby advertising IL-10 release. LPS regulated Src homology region 2 domain-containing phosphatase-1 (SHP-1) expression and p38 mitogen-activated necessary protein kinase