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Introduction Acute care surgery (ACS) was initiated two decades ago to address timeliness and quality in emergency general surgery. We hypothesized that ACS has improved the management of acute appendicitis and biliary disease. Methods A comprehensive systematic review and meta-analysis of outcome studies for emergent appendectomy and cholecystectomy from 1966 to 2017, comparing studies prior to and following ACS implementation. Results Of 1704 studies, 27 were selected for analysis (appendicitis = 16, biliary pathology= 7, both = 4). Foll