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Our choosing suggests that despair could adversely influence intellectual purpose, and despair treatment may have advantageous cognitive impact both in advertising and LLD. This study indicates the importance of early recognition and treatment of depression in AD and LLD. Trial subscription medical Research Ideas provider, CRIS, ID# KCT0004041, Registered 5 Summer 2019, retrospectively signed up after very first client enrollment time (4 March 2014) https//cris.nih.go.kr/cris/