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Glioblastoma multiforme (GBM) is the deadliest form of brain tumour. It is known for its ability to escape the therapeutic options available to date, thanks to the presence of a subset of cells endowed with stem-like properties and able to resist to cytotoxic treatments. As the cytosolic enzyme aldehyde dehydrogenase 1A3 turns out to be overexpresses in this kind of cells, playing a key role for their vitality, treatments targeting this enzyme may represent a successful strategy to fight GBM. In this work we describe a novel class of im
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