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06 nM. Moreover, the ADME properties of the compounds were evaluated in silico, and the results revealed appropriate predictions.A series of new RuII Schiff base complexes built on the salphen moiety has been prepared. This includes four flexibile monometallic RuII compounds and six rigid bimetallic analogues that contain NiII, PdII or PtII cations into the salphen complexation site. Steady state luminescence titrations illustrated the capacity of the compounds to photoprobe G-quadruplex DNA. Moreover, the vast array of the Schiff base