https://www.selleckchem.com/pr....oducts/Amprenavir-(A
Using genetic screens and functional validation studies, the Src kinase LYN was identified as a potential regulator of OATP1B1 activity that is highly sensitive to inhibition by various TKIs at clinically relevant concentrations. A novel kinase-dependent post-translational mechanism of OATP1B1 activation was identified and interference with this process by TKIs can influence the elimination of a broad range of xenobiotic substrates. A novel kinase-dependent post-translational mechanism of OATP1B1 activation was identified
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