https://www.selleckchem.com/pr....oducts/shin1-rz-2994
The collecting duct (CD) is a major site of both biosynthesis and action of prostaglandin E as highlighted by the predominant expression of COX-2 (cyclooxygenase-2) and some E-prostanoid (EP) subtypes at this nephron site. The purpose of this study was to determine the relevance and mechanism of CD COX-2/prostaglandin E /EP signaling for the regulation of Na hemostasis during Na depletion. Mice with Aqp2Cre-driven deletion of COX-2 (COX-2 Aqp2Cre ) or the EP subtype (EP Aqp2Cre ) were generated and the Na -wasting phenotype of the
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