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Baseline characteristics between T2DM patients with and without DPN did not differ, except for the sex ratio. The mean serum NPY level was higher in T2DM patients with DPN than in those without DPN ( = 0.0328), whereas serum SLPI levels did not differ ( = 0.9651). In the pathogenesis of DPN, may play a protective role in the peripheral nervous system and may be useful as a biomarker for detecting T2DM DPN. In the pathogenesis of DPN, NPY may play a protective role in the peripheral nervous system and may be useful as a biomarker for d