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CONCLUSION There is no conclusive evidence that HRQoL differs between term-born adults and those born VPT or with a VLBW. The comparability of studies was restricted by differences between HRQoL measurements, age ranges at assessment and definition of disability. © 2020 The Authors. Acta Paediatrica published by John Wiley Sons Ltd on behalf of Foundation Acta Paediatrica.BACKGROUND Anti-PD1 immunotherapy has shown a sustainable clinical activity in patients with metastatic melanoma. However, strong predictive factors of the long-